Ankylosing Spondylitis

A chronic, progressive inflammatory disease of the spine that causes pain, stiffness, and reduced mobility — and can lead to permanent fusion of the vertebrae if left unmanaged. Early diagnosis and timely intervention are critical.

HLA-B27 key genetic marker present in ~90% of AS patients
Ankylosing Spondylitis

Symptoms

Ankylosing Spondylitis (AS) typically begins between ages 17 and 40 with early morning stiffness and back pain. Without proper management, it progresses — gradually restricting movement and, in severe cases, causing the spine to fuse into a fixed, immobile position. How AS progresses if left untreated: Early morning stiffness - Improves with movement Chronic back pain - Sacroiliac joints first, Reduced mobility - Lumbar, Cervical & thoracic spine, Bony bridging - Osteophytes form, Spinal fusion - "Bamboo spine" — irreversible
Spinal symptoms you may experience:

Early morning stiffness and pain in the lower back, neck, and hips — worst on waking, easing with movement

Increasing pain and difficulty with movement — bending, turning, or straightening the spine

Pain radiating from the buttocks into one or both legs — sacroiliac joint involvement

Pain spreading from the neck or upper back into the hands or fingers when discs are involved

Tingling, numbness, burning, or weakness in legs, feet, hands or fingers (disc involvement)

Pain worsening with prolonged rest or sitting — characteristically relieved by activity

Loss of bladder or bowel control in severe cases with cord involvement

Progressive loss of spinal flexibility — difficulty looking over the shoulder or bending forward

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